Injectable suspensions are heterogeneous systems consisting of a solid phase dispersed within a liquid phase. They must be sterile, pyrogen free and maintain suitable physical and chemical stability over the intended shelf-life. They are limited to s.c and i.m routes of administration i.v administration may result in vasoocclusion. They may usually contain between 0.5-5.0% solids and should have the particle size less than 5μm but certain antibiotic preparations may contain up to 0% solids.
Advantages of Injectable suspensions
Therapeutic use of drugs those are insoluble in conventional solvents (i.e. – aqueous, water miscible and water immiscible).
Increase chemical stability when compared to solution preparations
Possible for depot preparation
Elimination of first-pass effects..
Disadvantages of Injectable suspensions
Difficulty in formulation and manufacturing
Discomfort to patient
Difficulty in maintaining of uniformity of dose
Difficulty in maintenance of physical stability
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