Monday, November 1, 2010

Preservatives to control microbial growth:

Preservatives to control microbial growth is an important duration not only on the chemical stability of ingredients but also on the physical integrity of the system. Orally accepted preservatives such as parabens, benzoates and sorbates. The use of cationic antimicrobial agents such as benzalkonium chloride, is usually contraindicated, because cationic agents may be inactivated by formulation components or they may alter the charge of the suspended particles. A well preserved oral or topical suspension does not have to be sterile to prevent microbial growth. The sue of small amounts of propylene glycol (5-15%) disodium edtate (about 0.1%) or decrease of pH all have been used to increase the efficiency of preservative systems without adversely affecting physical stability of pharmaceutical suspensions.

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